Equipment
EQUIPMENT FOR PILOT-SCALE PRODUCTION OF DOSAGE FORMS
Solid dosage forms
- Pan coater GS FILM RA/F
- Pan coater Logica Progetti Tech 10
- Alternate tableting machine Korsch EK0
- Rotary tablet press Ronchi AM-8S e relativo sistema di acquisizione delle forze FDW Analyser
- Rotary tablet press Ronchi FA e relativo sistema di acquisizione delle forze
- Three-dimensional printer Cronoplast (for 3D printing of thermoplastic materials)
- Extractor (continuous mode) Soxlet
- Extruder (Extrusiograph 19/25 D, Brabender) equipped with cutter for spherical extrudates and data acquisition/analysis softwarei
- Single-screw extruder Brabender PL2000
- Extruder/sheronizer Nica System
- Extruder /bench-top twin-screw capillary rheometer Thermo Fisher HAAKE MiniLab II
- One-step high-shear granulator Rotolab Zanchetta
- Fluid bed apparatus Uniglatt
- Bench-top fluid bed apparatus Mini-Glatt
- Stator homogenizer Ultraturrax
- Injection-molding press Baby Plast 6/10P
- Fluid bed rotogranulator Glatt GPGC 1.1
- Sealing machine Mini Pack
- Bench-top single-arm FDM (Fused Deposition Modeling) 3D printer, Makerbot Replicator 2
- Bench-top dual-arm FDM 3D printer, Kloner3D 240 Twin
- 3D Discovery Evolution Bioprinter, Regen-Hu R-GEN 100 equipped with different printer heads
Freeze-dried products
- Freeze-dryer alpha 1-4 LSC
- Bench-top freeze-dryer (6 kg water) Martin Christ
Powders
- Ball mill Morandi
- Hammer mill Retsch ZM200
- Spray-dryer 4M8 PROCEPT
Topical dosage forms
- Stator homogenizer
- Mathis Labcoater type LTE-S(M)
- hot-melt ram-extrusion 3D printer
- Mini-extruder for liposome formulations (Avanti polar lipids, USA)
- Brookfield Viscosimeter
Parenteral dosage forms
- Autoclave (Tuttnauer 2540 mL)
- Shaking incubator (CERTOMAT IS, Sartorius)
EQUIPMENT FOR CHARACTERIZATION OF RAW MATERIALS AND PRODUCTS
In vitro skin and mucosal permeation
- Franz diffusion cells for in vitro evaluation of skin and transmucosal permeability of active ingredients
Solid state properties
- Differential scanning calorimeter MODULATO Mettler
- Thermobalance TA Instruments 2050
Mechanical properties
- Instron dynamometer equipped for measuring the mechanical properties of plastic materials, adhesives, and material with mucoadhesive properties
- ACQUATI AGMC1 dynamometer equipped for the measurement of the mechanical properties of plastic materials, siringability and injectability tests
- Plastometer
Granulometry and Particle size distribution
- Coulter Beckmann BET for surface area measurements
- Laser Diffraction Particle Size Analyzers For Both Wet And Dry Dispersion (Mastersizer 3000)
- Optical microscope Zeiss mod. Axiolab equipped for particle size analysis accordingto British Standard 3406
- Sieve shaker Endecotts mod. Octagon 200 for sieve analysis
- Dynamic light scattering, Malvern Zetasizer Nano SZ
- Nano tracking analysis, NanoSight NS300
Spectroscopy analysis
- High performance liquid chromatographs (HPLC) equipped with autosampler and the following detection systems: UV-DAD, and fluorimeter
- GPC equipped with RID detector
- UV-Vis spectrophotometers
Testing of dosage forms
- Dissolution apparatus Ph. Eur.
- Disaggregation apparatus Ph. Eur.
- Friability Test Instrument Erweka mod. TA3R
- Creep instrument (8 bank oven shear HT-8, Cheminstruments)
- Karl Fischer titrator (Mettler Toledo V20)
- Oscillating water bath (Julabo)