EQUIPMENT FOR PILOT-SCALE PRODUCTION OF DOSAGE FORMS

Solid dosage forms

• Pan coater GS FILM RA/F
• Pan coater Logica Progetti Tech 10
• Alternate tableting machine Korsch EK0
• Rotary tablet press Ronchi AM-8S e relativo sistema di acquisizione delle forze FDW Analyser
• Rotary tablet press Ronchi FA e relativo sistema di acquisizione delle forze
• Three-dimensional printer Cronoplast (for 3D printing of thermoplastic materials)
• Extractor (continuous mode) Soxlet
• Extruder (Extrusiograph 19/25 D, Brabender) equipped with cutter for spherical extrudates and data acquisition/analysis softwarei
• Single-screw extruder Brabender PL2000
• Extruder/sheronizer Nica System
• Extruder /bench-top twin-screw capillary rheometer Thermo Fisher HAAKE MiniLab II
• One-step high-shear granulator Rotolab Zanchetta
• Fluid bed apparatus Uniglatt
• Bench-top fluid bed apparatus Mini-Glatt
• Stator homogenizer Ultraturrax
• Injection-molding press Baby Plast 6/10P
• Fluid bed rotogranulator Glatt GPGC 1.1
• Sealing machine Mini Pack
• Bench-top single-arm FDM (Fused Deposition Modeling) 3D printer, Makerbot Replicator 2
• Bench-top dual-arm FDM 3D printer, Kloner3D 240 Twin
• 3D Discovery Evolution Bioprinter, Regen-Hu R-GEN 100 equipped with different printer heads

Freeze-dried products

• Freeze-dryer alpha 1-4 LSC
• Bench-top freeze-dryer (6 kg water) Martin Christ

Powders

• Ball mill Morandi
• Hammer mill Retsch ZM200
• Spray-dryer 4M8 PROCEPT

Topical dosage forms

• Stator homogenizer
• Mathis Labcoater type LTE-S(M)
• hot-melt ram-extrusion 3D printer
• Mini-extruder for liposome formulations (Avanti polar lipids, USA)
• Brookfield Viscosimeter

Parenteral dosage forms

• Autoclave (Tuttnauer 2540 mL)
• Shaking incubator (CERTOMAT IS, Sartorius)

EQUIPMENT FOR CHARACTERIZATION OF RAW MATERIALS AND PRODUCTS

In vitro skin and mucosal permeation

• Franz diffusion cells for in vitro evaluation of skin and transmucosal permeability of active ingredients

Solid state properties

• Differential scanning calorimeter MODULATO Mettler
• Thermobalance TA Instruments 2050

Mechanical properties

• Instron dynamometer equipped for measuring the mechanical properties of plastic materials, adhesives, and material with mucoadhesive properties
• ACQUATI AGMC1 dynamometer equipped for the measurement of the mechanical properties of plastic materials, siringability and injectability tests
• Plastometer

Granulometry and Particle size distribution

• Coulter Beckmann BET for surface area measurements
• Laser Diffraction Particle Size Analyzers For Both Wet And Dry Dispersion (Mastersizer 3000)
• Optical microscope Zeiss mod. Axiolab equipped for particle size analysis accordingto British Standard 3406
• Sieve shaker Endecotts mod. Octagon 200 for sieve analysis
• Dynamic light scattering, Malvern Zetasizer Nano SZ
• Nano tracking analysis, NanoSight NS300

Spectroscopy analysis

• High performance liquid chromatographs (HPLC) equipped with autosampler and the following detection systems: UV-DAD, and fluorimeter
• GPC equipped with RID detector
• UV-Vis spectrophotometers

Testing of dosage forms

• Dissolution apparatus Ph. Eur.
• Disaggregation apparatus Ph. Eur.
• Friability Test Instrument Erweka mod. TA3R
• Creep instrument (8 bank oven shear HT-8, Cheminstruments)
• Karl Fischer titrator (Mettler Toledo V20)
• Oscillating water bath (Julabo)